Article
Potent and Selective Modulation of the RhlR Quorum Sensing Receptor by Using Non-native Ligands: An Emerging Target for Virulence Control in Pseudomonas aeruginosa.
Chembiochem : a European journal of chemical biology - 2 Nov 2015
Eibergen Nora R, Moore Joseph D, Mattmann Margrith E, Blackwell Helen E
Abstract excerpt
Pseudomonas aeruginosa uses N-acylated L-homoserine lactone signals and a triumvirate of LuxR-type receptor proteins--LasR, RhlR, and QscR--for quorum sensing (QS). Each of these receptors can contribute to QS activation or repression and, thereby, the control of myriad virulence phenotypes in this pathogen. LasR has traditionally been considered to be at the top of the QS receptor hierarchy in P. aeruginosa;...
Topics
- 4-Butyrolactone
- Bacterial Proteins
- Escherichia coli
- Genes, Reporter
- Ligands
- Phenotype
- Protein Binding
- Pseudomonas aeruginosa
- Quorum Sensing
- Small Molecule Libraries