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Article

Intraspecies Signaling between Common Variants of Pseudomonas aeruginosa Increases Production of Quorum-Sensing-Controlled Virulence Factors.

mBio - 25 Aug 2020

Mould Dallas L, Botelho Nico J, Hogan Deborah A

Abstract excerpt

The opportunistic pathogen Pseudomonas aeruginosa damages hosts through the production of diverse secreted products, many of which are regulated by quorum sensing (QS). The lasR gene, which encodes a central QS regulator, is frequently mutated in clinical isolates from chronic infections, and loss of LasR function (LasR-) generally impairs the activity of downstream QS regulators RhlR and PqsR. We found that in...

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Identifiers

PMID: 32843558
DOI: 10.1128/mBio.01865-20
PMCID: PMC7448281

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