Article

Mavacamten stabilizes the auto-inhibited state of two-headed cardiac myosin

2018-03-22

Abstract excerpt

We used transient biochemical and structural kinetics to elucidate the molecular mechanism of mavacamten, an allosteric cardiac myosin inhibitor and prospective treatment for hypertrophic cardiomyopathy. We find that mavacamten stabilizes an auto-inhibited state of two-headed cardiac myosin, not found in the isolated S1 myosin motor fragment. We determined this by measuring cardiac myosin actin-activated and actin...

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Literature Corpus work: c9bda61a-f0c9-5958-8873-ba2b12189bd2
DOI: 10.1101/287425

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