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Article

Mutation-induced free-energy remodeling of recovery stroke and ATP hydrolysis in human cardiac β-myosin.

Biophysical journal - 15 Sept 2026

Ghanta Krishna Prasad, Roy Rakesh Kumar, Tardiff Jil C, Schwartz Steven D

Abstract excerpt

Human cardiac muscle function is regulated by interactions between the thick (myosin) and thin (actin) filaments, driven by conformational changes in myosin coupled to ATP hydrolysis, enabling force generation. During the recovery stroke, myosin undergoes conformational rearrangements that position active site residues for ATP hydrolysis and actin interaction, making it a critical step in the kinetic cycle....

Read the complete abstract on PubMed

Topics

Humans
Hydrolysis
Adenosine Triphosphate
Mutation
Thermodynamics
Kinetics
Ventricular Myosins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Models, Molecular

Molecular Dynamics Simulation

Protein Conformation

Source

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Identifiers

PMID: 41918169
DOI: 10.1016/j.bpj.2026.03.056
PMCID: PMC13138891

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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