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Article

Functional adaptation of the switch-2 nucleotide sensor enables rapid processive translocation by myosin-5.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2010

Nagy Nikolett T, Sakamoto Takeshi, Takács Balázs, Gyimesi Máté, Hazai Eszter, Bikádi Zsolt, Sellers James R, Kovács Mihály

Abstract excerpt

Active site loops that are conserved across superfamilies of myosins, kinesins, and G proteins play key roles in allosteric coupling of NTP hydrolysis to interaction with track filaments or effector proteins. In this study, we investigated how the class-specific natural variation in the switch-2 active site loop contributes to the motor function of the intracellular transporter myosin-5. We used single-molecule,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20631329
DOI: 10.1096/fj.10-163998
PMCID: PMC2974419

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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