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The protein phosphatase 2C domain contributes to the pathobiological function of adenylyl cyclase in <i>Cryptococcus neoformans</i>

2025-12-11

Abstract excerpt

<h4>ABSTRACT</h4> Adenylyl cyclase (AC) is the central regulator of cAMP signalling in fungal pathogens, yet fungal ACs uniquely contain a protein phosphatase 2C (PP2C) domain whose function remains unclear. Here, we characterise the PP2C domain of the AC Cac1 in the human pathogen Cryptococcus neoformans . Structural and biochemical analyses show that Cac1-PP2C adopts a non-canonical scaffold but functions as a...

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Literature Corpus work
c351071b-2b59-580b-8187-ae0038404d2c
DOI
10.64898/2025.12.10.693573
Open publication

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The protein phosphatase 2C domain contributes to the pathobiological function of adenylyl cyclase in <i>Cryptococcus neoformans</i>DOI 10.64898/2025.12.10.693573
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