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Article

Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans.

Eukaryotic cell - 1 Feb 2002

Alspaugh J Andrew, Pukkila-Worley Read, Harashima Toshiaki, Cavallo Lora M, Funnell Deanna, Cox Gary M, Perfect John R, Kronstad James W, Heitman Joseph

Abstract excerpt

The signaling molecule cyclic AMP (cAMP) is a ubiquitous second messenger that enables cells to detect and respond to extracellular signals. cAMP is generated by the enzyme adenylyl cyclase, which is activated or inhibited by the Galpha subunits of heterotrimeric G proteins in response to ligand-...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12455973
DOI: 10.1128/EC.1.1.75-84.2002
PMCID: PMC118042

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12455973-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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