Article

Thermoregulation network governing virulence of a critical human fungal pathogen

2025-08-18

Abstract excerpt

Cryptococcus neoformans is an environmental fungal pathogen that causes meningoencephalitis in humans, requiring thermal adaptation to human body temperature. We employed several orthogonal complementary approaches to elucidate molecular mechanisms of calcineurin signaling, which is essential for thermotolerance of many fungal species, and in so doing, delineated a thermoregulatory network. First, genetic suppress...

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Literature Corpus work: f95a0b9c-545e-5acb-b465-16f9547dbd03
DOI: 10.1101/2025.08.18.670910

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