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Genome-wide functional analysis of phosphatases in the pathogenic fungus Cryptococcus neoformans

24 Aug 2020

Abstract excerpt

Phosphatases, together with kinases and transcription factors, are key components in cellular signalling networks. Here, we present a systematic functional analysis of the phosphatases in Cryptococcus neoformans, a fungal pathogen that causes life-threatening fungal meningoencephalitis. We analyse 230 signature-tagged mutant strains for 114 putative phosphatases under 30 distinct in vitro growth conditions,...

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PMID: 32839469
DOI: 10.1038/s41467-020-18028-0

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