Article
Adenylyl Cyclase and Protein Kinase A Play Redundant and Distinct Roles in Growth, Differentiation, Antifungal Drug Resistance, and Pathogenicity of Candida auris.
mBio - 26 Oct 2021
Kim Ji-Seok, Lee Kyung-Tae, Lee Myung Ha, Cheong Eunji, Bahn Yong-Sun
Abstract excerpt
Candida auris is a globally emerging multidrug-resistant fungal pathogen. Its pathogenicity-related signaling networks are largely unknown. Here, we characterized the pathobiological functions of the cyclic AMP (cAMP)/protein kinase A (PKA) signaling pathway in C. auris. We focused on adenylyl cyclase (CYR1), the PKA regulatory subunit (BCY1), and the PKA catalytic subunits (TPK1 and TPK2). We concluded that PKA...
Topics
- Adenylyl Cyclases
- Animals
- Antifungal Agents
- Biofilms
- Candida auris
- Candidiasis
- Cyclic AMP
- Cyclic AMP-Dependent Protein Kinases
- Drug Resistance, Fungal
- Female
- Gene Expression Regulation, Fungal
- Mice
- Phenotype
- Signal Transduction