Back to search

Article

Distinct pathways of adaptive evolution in <i>Cryptococcus neoformans</i> reveal a point mutation in adenylate cyclase with drastic tradeoffs for pathogenicity

2022-09-28

Abstract excerpt

Pathogenic fungi populate a wide range of environments and infect a diversity of host species. Despite this substantial biological flexibility, the impact of interactions between fungi and their hosts on the evolution of pathogenicity remains unclear. We studied how repeated interactions between the fungus Cryptococcus neoformans and relevant environmental and mammalian host cells—amoeba and mouse macrophages—sha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5813e26f-f7fa-5486-a04a-f62c8424525d
DOI
10.1101/2022.09.27.509772
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Distinct pathways of adaptive evolution in <i>Cryptococcus neoformans</i> reveal a point mutation in adenylate cyclase with drastic tradeoffs for pathogenicityDOI 10.1101/2022.09.27.509772
Distinct pathways of adaptive evolution in Cryptococcus neoformans reveal a mutation in adenylyl cyclase with trade-offs for pathogenicity.Semantic proximity
Amoeba predation of <i>Cryptococcus neoformans</i> results in pleiotropic changes to traits associated with virulenceSemantic proximity
Phenotypic landscape of a fungal meningitis pathogen reveals its unique biologySemantic proximity
The protein phosphatase 2C domain contributes to the pathobiological function of adenylyl cyclase in <i>Cryptococcus neoformans</i>Semantic proximity
Amoeba Predation of Cryptococcus neoformans Results in Pleiotropic Changes to Traits Associated with Virulence.Semantic proximity
Distinct routes to thermotolerance in the fungal pathogen <i>Cryptococcus neoformans</i>Semantic proximity
Phenotypic landscape of an invasive fungal pathogen reveals its unique biology.Semantic proximity
Genome restructuring and lineage diversification of<i>Cryptococcus neoformans</i>during chronic infection of human hostsSemantic proximity
Genome-guided manipulation of regulators of morphogenesis in a <i>C. albicans</i> strain with low virulence is not sufficient to trigger a high-virulence phenotypeSemantic proximity
The protein phosphatase 2C domain contributes to the pathobiological function of adenylyl cyclase in Cryptococcus neoformansSemantic proximity
An evolutionary genomic approach reveals both conserved and species-specific genetic elements related to human disease in closely related <i>Aspergillus</i> fungiSemantic proximity
Microevolution of Cryptococcus neoformans in high CO2 converges on mutations isolated from patients with relapsed cryptococcosis.Semantic proximity
Select a neighboring publication to make it the new centre.