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The protein phosphatase 2C domain contributes to the pathobiological function of adenylyl cyclase in Cryptococcus neoformans

2026-01-13

Abstract excerpt

<title>Abstract</title> <p> Adenylyl cyclase (AC) is the central regulator of cAMP signalling in fungal pathogens, yet fungal ACs uniquely contain a protein phosphatase 2C (PP2C) domain whose function remains unclear. Here, we characterise the PP2C domain of the AC Cac1 in the human pathogen <italic>Cryptococcus neoformans</italic> . Structural and biochemical analyses show that Cac1-PP2C adopts a non-canonica...

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Literature Corpus work
3faa7661-bf9f-5ee1-8de5-635b69e03483
DOI
10.21203/rs.3.rs-8322199/v1
Open publication

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The protein phosphatase 2C domain contributes to the pathobiological function of adenylyl cyclase in Cryptococcus neoformansDOI 10.21203/rs.3.rs-8322199/v1
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