TrkA ⁺ sensory neurons regulate osteosarcoma proliferation and vascularization to promote disease progression

Abstract excerpt

Bone pain is a presenting feature of bone cancers such as osteosarcoma (OS), relayed by skeletal-innervating peripheral afferent neurons. Potential functions of tumor-associated sensory neurons in bone cancers beyond pain sensation are unknown. To uncover neural regulatory functions, a chemical-genetic approach in mice with a knock-in allele for TrkA was used to functionally perturb sensory nerve innervation durin...

Topics

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• Bone Neoplasms
• Cancer, Stress, Anesthesia, and Immune Response
• Genetic Predisposition to Disease
• Mice
• Mutagenesis, Insertional
• Neuropeptides and Animal Physiology
• Pain Mechanisms and Treatments
• Receptor Mechanisms and Signaling

Identifiers and source

Literature Corpus work

4e7734d2-11ef-5eeb-ab3d-20d52f225c30

DOI

10.1101/2024.06.20.599869