Article

Profibrotic priming of airway cell types and drug responses in early-stage idiopathic pulmonary fibrosis

2022-03-09

Abstract excerpt

Early genetic studies hinted the role of airway epithelial cells in the development of idiopathic pulmonary fibrosis (IPF), while recent single-cell RNA sequencing (scRNA-seq) atlases utilized explant IPF lungs and therefore represent late-stage disease. Here, we used air liquid interface (ALI) cultures of primary cells taken from the subsegmental bronchi of newly diagnosed IPF patients, reflecting early-stage fib...

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Literature Corpus work: 67ddda98-5821-5423-9660-15edbcce6968
DOI: 10.1101/2022.03.09.483638

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