Article

Tracing the origin of pathologic pulmonary fibroblasts

2022-11-18

Abstract excerpt

Fibroblasts substantially remodel extracellular matrix (ECM) in response to tissue injury and generate fibrotic scars in chronic diseases. Recent studies have identified diverse fibroblast subsets in healthy and injured tissues. However, the origin(s) and functional importance of injury-induced fibroblast lineages remain unclear. Here we show that alveolar fibroblasts, which provide a niche for maintaining alveola...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 03753a63-ee54-5633-a562-fdff378b5de0
DOI: 10.1101/2022.11.18.517147

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tracing the origin of pathologic pulmonary fibroblastsDOI 10.1101/2022.11.18.517147Read

Dissecting pulmonary fibroblasts heterogeneity in lung development, health and diseasesSemantic proximity Read

Transcriptional and spatial profiling of fibroblasts from human lungs highlights CTHRC1+ cells as fibrogenic signaling hubs in fibrosisSemantic proximity Read

Inflammatory Fibroblasts Promote Repair After Injury Through Epithelial ProliferationSemantic proximity Read

Sfrp1 inhibits lung fibroblast invasion during transition to injury-induced myofibroblastsSemantic proximity Read

Definition and Signatures of Lung Fibroblast Populations in Development and Fibrosis in Mice and MenSemantic proximity Read

Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis.Semantic proximity Read

Translational mapping of spatially resolved transcriptomes in human and mouse pulmonary fibrosisSemantic proximity Read

Mapping spatially resolved transcriptomes in human and mouse pulmonary fibrosisSemantic proximity Read

Mechanisms and Therapeutic Potential of Myofibroblast Transformation in Pulmonary FibrosisSemantic proximity Read

RNA-sequencing comparison of pneumonectomy and bleomycin reveals anti-fibrotic mechanisms of lung fibroblastsSemantic proximity Read

Lung Pericytes and Resident Fibroblasts: Busy Multitaskers.Semantic proximity Read

Evidence for a lipofibroblast-to- Cthrc1 + myofibroblast reversible switch during the development and resolution of lung fibrosis in young miceSemantic proximity Read