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Article

Sfrp1 inhibits lung fibroblast invasion during transition to injury-induced myofibroblasts

11 Jan 2024

Abstract excerpt

Background Fibroblast-to-myofibroblast conversion is a major driver of tissue remodelling in organ fibrosis. Distinct lineages of fibroblasts support homeostatic tissue niche functions, yet their specific activation states and phenotypic trajectories during injury and repair have remained unclear. Methods We combined spatial transcriptomics, multiplexed immunostainings, longitudinal single-cell RNA-sequencing and...

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PMID: 38212077
DOI: 10.1183/13993003.01326-2023

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