Article

Lineage-associated tumor cell states predict outcome and guide immunotherapeutic target selection in pediatric osteosarcoma

2026-06-16

Abstract excerpt

Osteosarcoma is a highly heterogeneous primary bone malignancy that predominantly affects adolescents and young adults, and robust prognostic biomarkers and effective targeted therapies remain lacking. While single-cell transcriptomics has begun to resolve tumor composition, a tumor cell–intrinsic framework linking transcriptional states to clinical outcome and therapeutic targeting is not established. Here, we pr...

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Literature Corpus work: c33132c5-33d7-5a1c-a5f4-c5db26fb3b1b
DOI: 10.64898/2026.06.11.731770

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