Article

Single-Cell and Spatial Profiling of Tumor Microenvironment Heterogeneity in Human Osteosarcomas

2025-07-02

Abstract excerpt

Osteosarcoma, a highly heterogeneous malignant bone tumor, exhibits substantial interpatient and intratumoral heterogeneity. Utilizing integrated single-cell RNA sequencing and spatial transcriptomics, we uncovered distinct tumor microenvironment (TME) transcriptional profiles across patients, highlighting profound interpatient heterogeneity. Intratumorally, malignant cells primarily followed two differentiation t...

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Literature Corpus work: 1213b397-e35c-5eb8-b8a2-f728539777b0
DOI: 10.1101/2025.06.27.661729

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