Article

Single-cell and pseudobulk transcriptomic profiling reveals immune-enriched disease- associated signatures in human pancreatic islets from type 2 diabetes

2026-06-30

Abstract excerpt

<title>Abstract</title> <p>Background Type 2 diabetes (T2D) is a multifactorial metabolic disorder characterized by impaired glucose homeostasis, insulin resistance, and progressive dysfunction of pancreatic islet cells. Given the cellular heterogeneity of human pancreatic islets, bulk transcriptomic approaches may obscure cell type-specific disease signals. Single-cell RNA sequencing provides an opportunity to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8df32575-54ed-530f-adee-c736157986ae
DOI: 10.21203/rs.3.rs-10040418/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell and pseudobulk transcriptomic profiling reveals immune-enriched disease- associated signatures in human pancreatic islets from type 2 diabetesDOI 10.21203/rs.3.rs-10040418/v1Read

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetesSemantic proximity Read

PanKbase Integrated Single-Cell Map: A Comprehensive Atlas of Human Pancreatic IsletsSemantic proximity Read

Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learningSemantic proximity Read

Transcriptomic Architecture of Type 2 Diabetes in Human Pancreatic Islets: An Integrative Meta-Analysis and Machine Learning Framework for Biomarker DiscoverySemantic proximity Read

Multiomics single-cell analysis of human pancreatic islets reveals novel cellular states in health and type 1 diabetesSemantic proximity Read

Deciphering the Transcriptomic Landscape of Type 2 Diabetes: Insights from Bulk RNA Sequencing and Single-Cell AnalysisSemantic proximity Read

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetesSemantic proximity Read

Identification of unique cell type responses in pancreatic islets to stressSemantic proximity Read

Single-cell mRNA-regulation analysis reveals cell type-specific mechanisms of type 2 diabetesSemantic proximity Read

Computational workflow and interactive analysis of single-cell expression profiling of islets generated by the Human Pancreas Analysis ProgramSemantic proximity Read

Single-cell decoding of human islet cell type-specific alterations in type 2 diabetes reveals converging genetic- and state-driven β-cell gene expression defectsSemantic proximity Read

Integrated meta-analysis of public human pancreatic single-cell transcriptomes reveals distinct beta-cell state trajectories across aging and diabetesSemantic proximity Read