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Application of human iPSC-derived white, beige, and brown adipocytes for metabolic disease modeling and transplantation therapy

19 Jun 2025

Abstract excerpt

Adipocyte dysfunction plays a critical role in the pathogenesis of metabolic diseases, including type 2 diabetes (T2D). Human induced pluripotent stem cells (hiPSCs) offer a powerful platform for generating white, beige, and brown adipocytes, supporting both disease modeling and therapeutic research. This review provides a comprehensive summary of current differentiation methods to produce three functionally...

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Share to Adipose Tissue and Metabolism
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PMID: 40537438
DOI: 10.1177/09636897251346599

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