Article

SRSF3 knockdown-induced cellular senescence as a possible therapeutic strategy for non-small cell lung cancer

2025-05-09

Abstract excerpt

Tyrosine kinase (TK) inhibitors improve clinical outcomes in non-small cell lung cancer (NSCLC) with targetable mutations. However, such NSCLC cases only consist of about 50% in the western populations. This study, for the first time in NSCLC cells including those without a targetable TK mutation, explores a tumor-suppressive activity of siRNA knockdown of a splicing factor SRSF3, which was reportedly effective in...

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Literature Corpus work: c2f4d486-870d-5848-87ee-9ec23908e5fa
DOI: 10.1101/2025.05.05.652234

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