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Article

Gefitinib induces premature senescence in non-small cell lung cancer cells with or without EGFR gene mutation.

Oncology reports - 1 Feb 2007

Hotta Katsuyuki, Tabata Masahiro, Kiura Katsuyuki, Kozuki Toshiyuki, Hisamoto Akiko, Katayama Hideki, Takigawa Nagio, Fujimoto Nobukazu, Fujiwara Keiichi, Ueoka Hiroshi, Tanimoto Mitsune

Abstract excerpt

Despite its tremendous antitumor effect in a subset of patients with non-small cell lung cancer (NSCLC), the exact mechanism of gefitinib-induced cell death has not been fully determined. In this study, forms of cell death in various NSCLC cell lines after gefitinib exposure was analyzed to eluci...

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Identifiers

PMID: 17203166

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17203166-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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