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Article

Targeting the SREBP-1/Hsa-Mir-497/SCAP/FASN Oncometabolic Axis Inhibits the Cancer Stem-like and Chemoresistant Phenotype of Non-Small Cell Lung Carcinoma Cells.

International journal of molecular sciences - 30 Jun 2022

Tiong Tung-Yu, Weng Pei-Wei, Wang Chun-Hua, Setiawan Syahru Agung, Yadav Vijesh Kumar, Pikatan Narpati Wesa, Fong Iat-Hang, Yeh Chi-Tai, Hsu Chia-Hung, Kuo Kuang-Tai

Abstract excerpt

BACKGROUND: Lung cancer remains a leading cause of cancer-related death, with an annual global mortality rate of 18.4%. Despite advances in diagnostic and therapeutic technologies, non-small cell lung carcinoma (NSCLC) continues to be characterized by a poor prognosis. This may be associated with the enrichment of cancer stem cells (CSCs) and the development of chemoresistance-a double-edged challenge that...

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Identifiers

PMID: 35806291
DOI: 10.3390/ijms23137283
PMCID: PMC9266857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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