Article

Pemetrexed induces ROS generation and cellular senescence by attenuating TS-mediated thymidylate metabolism to reverse gefitinib resistance in non-small cell lung cancer

2022-10-18

Abstract excerpt

<title>Abstract</title> <p>Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are strongly recommended for non-small cell lung carcinoma (NSCLC) patients harboring active EGFR mutations, while drug resistance inevitably makes exploring the resistance mechanisms and seeking effective therapeutic strategies urgent endeavors. Thymidylate synthetase (TYMS or TS) is a dominant enzyme in thymidylat...

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Literature Corpus work: 317124be-dcae-5fe8-9912-b6cf42d1ff51
DOI: 10.21203/rs.3.rs-2135034/v1

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