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Article

TP53 drives abscopal effect by secretion of senescence-associated molecular signals in non-small cell lung cancer

5 Mar 2021

Abstract excerpt

BACKGROUND: Recent developments in abscopal effect strongly support the use of radiotherapy for the treatment of metastatic disease. However, deeper understanding of the molecular mechanisms underlying the abscopal effect are required to best benefit a larger proportion of patients with metastasis. Several groups including ours, reported the involvement of wild-type (wt) p53 in radiation-induced abscopal effects,...

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PMID: 33673859
DOI: 10.1186/s13046-021-01883-0

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