Article
RASSF3 downregulation increases malignant phenotypes of non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) - 1 Jan 2014
Fukatsu Asuki, Ishiguro Futoshi, Tanaka Ichidai, Kudo Takumi, Nakagawa Kentaro, Shinjo Keiko, Kondo Yutaka, Fujii Makiko, Hasegawa Yoshinori, Tomizawa Kenji, Mitsudomi Tetsuya, Osada Hirotaka, Hata Yutaka, Sekido Yoshitaka
Abstract excerpt
BACKGROUND: Ras-Association Family1A (RASSF1A) is a well-established tumor suppressor. Ten RASSF homologues comprise this family, and each member is considered a tumor suppressor. RASSF3 is one of the RASSF family members, but its function has not yet been clarified. Recently, we found that RASSF3 interacts with MDM2 and facilitates its ubiquitination, which induces apoptosis through p53 stabilization. However,...
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