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Article

eIF3a R803K mutation mediates chemotherapy resistance by inducing cellular senescence in small cell lung cancer.

Pharmacological research - 1 Dec 2021

Chen Yi-Xin, Wang Chen-Jing, Xiao De-Sheng, He Bai-Mei, Li Min, Yi Xiao-Ping, Zhang Wei, Yin Ji-Ye, Liu Zhao-Qian

Abstract excerpt

Drug resistance in small cell lung cancer (SCLC) significantly affects the efficacy of chemotherapy treatment. However, due to the lack of tumor tissue samples, especially serial tumor samples during chemotherapy, the mechanism of chemotherapy resistance has not been fully studied. Circulating tumor DNA, which can be obtained in a noninvasive manner, can complement tumor sampling approaches for research in this...

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PMID: 34648968
DOI: 10.1016/j.phrs.2021.105934

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