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Article

SRSF3 knockdown-induced cellular senescence as a possible therapeutic strategy for non-small cell lung cancer.

Carcinogenesis - 21 Nov 2025

Nakamichi Shinji, von Muhlinen Natalia, Yamada Leo, Melamed Jilian R, Papp Tyler E, Parhiz Hamideh, Weissman Drew, Horikawa Izumi, Harris Curtis C

Abstract excerpt

Tyrosine kinase (TK) inhibitors improve clinical outcomes in non-small cell lung cancer (NSCLC) with targetable mutations. However, such NSCLC cases account for only about 50% in the western populations. Inhibition of the splicing factor SRSF3 has been reported to be tumor-suppressive in other cancer cell types. This study for the first time explores the tumor-suppressive activity of siRNA knockdown of SRSF3 in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41225668
DOI: 10.1093/carcin/bgaf082
PMCID: PMC12629605

Genes

SRSF3
TP53
ASPM
EGFR
TOP2A
UBE2C

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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