Back to search

Article

Hyaluronan Underlies the Emergence of Form, Fate, and Function in Human Cardioids

2026-01-28

Abstract excerpt

<h4>ABSTRACT</h4> The extracellular matrix (ECM) is crucial for organ development and disease. Yet, the interplay among cells, function, and the ECM during human cardiogenesis remains obscure. Using human cardioids, we discovered that cardiac mesoderm-synthesized hyaluronan (HA) underlies early cardiac functional development. HA drives cardioid cavity formation through hydrogel swelling and bioscaffolding, critic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a3069af3-136e-5c61-8a32-9fd922c95317
DOI
10.64898/2026.01.26.700345
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Hyaluronan Underlies the Emergence of Form, Fate, and Function in Human CardioidsDOI 10.64898/2026.01.26.700345
The ECM as a driver of heart development and repairSemantic proximity
Multi-chamber cardioids unravel human heart development and cardiac defectsSemantic proximity
Inspiration from heart development: Biomimetic development of functional human cardiac organoids.Semantic proximity
Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytesSemantic proximity
Self-assembling human heart organoids for the modeling of cardiac development and congenital heart diseaseSemantic proximity
Self-assembling human heart organoids for the modeling of cardiac development and congenital heart diseaseSemantic proximity
Spatial Dynamics of the Developing Human HeartSemantic proximity
Leaf-venation-directed cellular alignment for macroscale cardiac constructs with tissue-like functionalitiesSemantic proximity
Developmentally inspired bioprinting of nascent multicellular human heart tissue through <i>in situ</i> differentiation and morphogenesis of iPSCsSemantic proximity
Cardiac ECM: Its Epigenetic Regulation and Role in Heart Development and RepairSemantic proximity
In vitro models of the human heartSemantic proximity
Leaf-venation-directed cellular alignment for macroscale cardiac constructs with tissue-like functionalitiesSemantic proximity
Select a neighboring publication to make it the new centre.