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Article

Predicting organoid morphology through a phase field model: Insights into cell division and lumenal pressure.

PLoS computational biology - 1 Aug 2025

Tanida Sakurako, Fuji Kana, Lu Linjie, Guyomar Tristan, Lee Byung Ho, Honigmann Alf, Grapin-Botton Anne, Riveline Daniel, Hiraiwa Tetsuya, Nonomura Makiko, Sano Masaki

Abstract excerpt

Organoids are ideal systems to predict the phenotypes of organs. However, there is currently a lack of understanding regarding the generalized rules that enable use of simple cellular principles to make morphological predictions of entire organoids. Therefore, we employed a phase field model with the following basic components: the minimum conditions for the timing and volume of cell division, lumen nucleation...

Read the complete abstract on PubMed

Topics

Organoids
Cell Division
Models, Biological
Humans
Cell Proliferation
Computational Biology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Phenotype

Animals

Cell Differentiation

Computer Simulation

Source

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Identifiers

PMID: 40825079
DOI: 10.1371/journal.pcbi.1012090
PMCID: PMC12373292

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