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Article

Driving tumor-associated macrophages to a CXCL9Hi/SPP1Low phenotype eliminates pancreatic cancer.

Cell reports. Medicine - 18 Aug 2026

Nguyen Yen T M, Pfefferlé Marc, Oh Juhyun, Simpson Grant G, Walker Sierra A, Noguchi Shingo, Garris Christopher S, Deutsch-Williams Riley J, Wirapati Pratyaksha, De Stefano Federico, Goemans Marie, Dai Rui, Vinegoni Claudio, Fernández Del Castillo Carlos, Liss Andrew S, Pittet Mikael J, Weissleder Ralph

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers, with limited therapeutic options. Recent studies reveal the complex PDAC microenvironment, which fosters interactions between various cell types that contribute to immunosuppression. Among these, tumor-associated myeloid cells with a CXCL9-low, SPP1-high phenotype are particularly abundant and play a significant role in promoting...

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Pancreatic Neoplasms

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Source

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Identifiers

PMID: 42492520
DOI: 10.1016/j.xcrm.2026.102938
PMCID: PMC13522754

Genes

CXCL9
SPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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