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Article

Context-Specific Determinants of the Immunosuppressive Tumor Microenvironment in Pancreatic Cancer

9 Jan 2023

Abstract excerpt

Immunotherapies have shown benefits across a range of human cancers, but not pancreatic ductal adenocarcinoma (PDAC). Recent evidence suggests that the immunosuppressive tumor microenvironment (TME) constitutes an important roadblock to their efficacy. The landscape of the TME differs substantially across PDAC subtypes, indicating context-specific principles of immunosuppression. In this review, we discuss how...

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PMID: 36622087
DOI: 10.1158/2159-8290.cd-22-0876

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