Article
The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9.
Nature immunology - 1 Nov 2016
Beatson Richard, Tajadura-Ortega Virginia, Achkova Daniela, Picco Gianfranco, Tsourouktsoglou Theodora-Dorita, Klausing Sandra, Hillier Matthew, Maher John, Noll Thomas, Crocker Paul R, Taylor-Papadimitriou Joyce, Burchell Joy M
Abstract excerpt
Siglec-9 is a sialic-acid-binding lectin expressed predominantly on myeloid cells. Aberrant glycosylation occurs in essentially all types of cancers and results in increased sialylation. Thus, when the mucin MUC1 is expressed on cancer cells, it is decorated by multiple short, sialylated O-linked glycans (MUC1-ST). Here we found that this cancer-specific MUC1 glycoform, through engagement of Siglec-9, 'educated'...
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