Article

Lnc- <i>ECAL-1</i> controls cerebrovascular homeostasis by targeting endothelium-specific tight junction protein <i>Cldn5b</i>

2020-01-31

Abstract excerpt

Cerebrovascular disorder-induced brain blood flow interruption or intracranial hemorrhage pose a great threaten to health. Emerging roles of long-noncoding RNAs (lncRNAs) in diagnosis and treatment of cardiovascular diseases have been recognized. However, whether and how lncRNAs modulate vascular homeostasis, especially network formation remain largely unknown. Here, we identified ECAL-1 , a long non-coding RNA,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c2d22d12-ae63-5659-8040-4f992ac9b14d
DOI: 10.1101/2020.01.30.926279

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lnc- <i>ECAL-1</i> controls cerebrovascular homeostasis by targeting endothelium-specific tight junction protein <i>Cldn5b</i>DOI 10.1101/2020.01.30.926279Read

Cerebral Cavernous Malformation Pathogenesis: Investigating Lesion Formation and Progression with Animal Models.Semantic proximity Read

Cerebral Cavernous Malformation: From Mechanism to Therapy.Semantic proximity Read

Persistent Activation of Endothelial Cells is Linked to Thrombosis and Inflammation in Cerebral Cavernous Malformation DiseaseSemantic proximity Read

From Genes and Mechanisms to Molecular-Targeted Therapies: The Long Climb to the Cure of Cerebral Cavernous Malformation (CCM) Disease.Semantic proximity Read

Transcriptome-wide Profiling of Cerebral Cavernous Malformations Patients Reveal Important Long noncoding RNA molecular signaturesSemantic proximity Read

Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypesSemantic proximity Read

MicroRNA-21-3p regulation of NOX4 and VEGFA contributes to hemorrhage in cerebral cavernous malformationsSemantic proximity Read

Cerebral cavernous malformations: from CCM genes to endothelial cell homeostasisSemantic proximity Read

Mutations of RNF213 are responsible for sporadic cerebral cavernous malformation and lead to a mulberry-like cluster in zebrafish.Semantic proximity Read

Loss of col4a1 in zebrafish recapitulates the cerebrovascular phenotypes associated with monogenic cerebral small vessel disease.Semantic proximity Read

ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish.Semantic proximity Read

Introduction to cerebral cavernous malformation: a brief review.Semantic proximity Read