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Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes

6 Feb 2019

Abstract excerpt

The purpose of this study was to determine important genes, functions, and networks contributing to the pathobiology of cerebral cavernous malformation (CCM) from transcriptomic analyses across 3 species and 2 disease genotypes. Sequencing of RNA from laser microdissected neurovascular units of 5 human surgically resected CCM lesions, mouse brain microvascular endothelial cells, Caenorhabditis elegans with...

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PMID: 30728328
DOI: 10.1172/jci.insight.126167

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