Article

Mining the Selective Remodeling of DNA Methylation in Promoter Regions to Identify Robust Gene-Level Associations with Phenotype

2020-01-06

Abstract excerpt

Epigenetics is an essential biological frontier linking genetics to the environment, where DNA methylation is one of the most studied epigenetic events. In recent years, through the epigenome-wide association study (EWAS), researchers have identified thousands of phenotype-related methylation sites. However, the overlap between identified phenotype-related DNA methylation sites are often quite small, and it might...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c2c68daa-904f-56a5-beb7-2869c56058cc
DOI: 10.1101/2020.01.05.895326

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mining the Selective Remodeling of DNA Methylation in Promoter Regions to Identify Robust Gene-Level Associations with PhenotypeDOI 10.1101/2020.01.05.895326Read

Revealing the architecture of genetic and epigenetic regulation: a maximum likelihood model.Semantic proximity Read

Predicting gene expression using DNA methylation in two human populationsSemantic proximity Read

Leveraging collective regulatory effects of long-range DNA methylations to predict gene expressions and estimate their effects on phenotypes in cancerSemantic proximity Read

Elucidating the genetic architecture of DNA methylation to identify promising molecular mechanisms of diseaseSemantic proximity Read

Elucidating the genetic architecture of DNA methylation to identify promising molecular mechanisms of disease.Semantic proximity Read

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic dataSemantic proximity Read

A tissue specific atlas of gene promoter DNA methylation variability and the clinical value of its assessmentSemantic proximity Read

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data.Semantic proximity Read

Integrative analysis of DNA methylation and gene expression data for the diagnosis and underlying mechanism of Parkinson’s diseaseSemantic proximity Read

A gene-level methylome-wide association analysis identifies novel Alzheimer’s disease genesSemantic proximity Read

Characterization and machine learning prediction of allele-specific DNA methylation.Semantic proximity Read

easyEWAS: a flexible and user-friendly R package for Epigenome-Wide Association StudySemantic proximity Read