Article

Leveraging collective regulatory effects of long-range DNA methylations to predict gene expressions and estimate their effects on phenotypes in cancer

2018-11-19

Abstract excerpt

<h4>ABSTRACT</h4> DNA methylation of various genomic regions plays an important role in regulating gene expression in diverse biological contexts. However, most genome-wide studies have focused on the effect of 1) methylation in cis , not in trans and 2) a single CpG, not the collective effects of multiple CpGs, on gene expression. In this study, we developed a statistical machine learning model, geneEXPLORER (...

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Literature Corpus work: 4d735cdd-7fdc-5dc6-87ab-99c611138b44
DOI: 10.1101/472589

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