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Article

Therapeutic Development by Targeting the cGAS-STING Pathway in Autoimmune Disease and Cancer

15 Nov 2021

Abstract excerpt

DNA immune recognition regulation mediated by the cGAS-STING pathway plays an important role in immune functions. Under normal physiological conditions, cGAS can recognize and bind to invading pathogen DNA and activate the innate immune response. On the other hand, abnormal activation of cGAS or STING is closely related to autoimmune diseases. In addition, activation of STING proteins as a bridge connecting...

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PMID: 34867409
DOI: 10.3389/fphar.2021.779425

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