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Alterations in cellular metabolisms after TKI therapy for Philadelphia chromosome-positive leukemia in children: A review

6 Dec 2022

Abstract excerpt

Incidence rates of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) are lower but more aggressive in children than in adults due to different biological and host factors. After the clinical application of tyrosine kinase inhibitor (TKI) blocking BCR/ABL kinase activity, the prognosis of children with CML and Ph+ ALL has improved dramatically. Yet,...

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PMID: 36561525
DOI: 10.3389/fonc.2022.1072806

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