Article

Profiling The Effect of Targeting Wild Isocitrate Dehydrogenase 1 (IDH1) on the Cellular Metabolome of Leukemic Cells

2022-06-09

Abstract excerpt

Leukemia represents as one of the most common primary malignancies of the hematologic system in both children’s and adults and remains a largely incurable or relapse disease. The elucidation of disease subtypes based on mutational profiling, has not improved clinical outcomes. IDH1/2 are key enzymes of TCA cycle that produces α-ketoglutarate (αKG), however their mutated version, are well reported...

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Literature Corpus work: 79e4d064-69a1-5a11-bbe7-4fa76557a103
DOI: 10.20944/preprints202206.0139.v1

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