Article

Expanding the Reach of RNAi Therapeutics with Next Generation Lipophilic siRNA Conjugates

2021-10-21

Abstract excerpt

<title>Abstract</title> <p>RNA interference (RNAi) therapeutics are a new class of medicines that can address unmet medical needs by silencing disease-causing gene transcripts. While delivery of short interfering RNAs (siRNAs) to hepatocytes has yielded multiple drug approvals, novel delivery solutions are needed to expand the reach of RNAi therapeutics. Here we report that conjugation of 2'-<italic>O</italic>-he...

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Literature Corpus work: 28b88cd8-5f1f-5647-afcf-725d2c84a383
DOI: 10.21203/rs.3.rs-946835/v1

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