Article
Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability.
Development (Cambridge, England) - 15 May 2017
Boretto Matteo, Cox Benoit, Noben Manuel, Hendriks Nikolai, Fassbender Amelie, Roose Heleen, Amant Frédéric, Timmerman Dirk, Tomassetti Carla, Vanhie Arne, Meuleman Christel, Ferrante Marc, Vankelecom Hugo
Abstract excerpt
The endometrium, which is of crucial importance for reproduction, undergoes dynamic cyclic tissue remodeling. Knowledge of its molecular and cellular regulation is poor, primarily owing to a lack of study models. Here, we have established a novel and promising organoid model from both mouse and human endometrium. Dissociated endometrial tissue, embedded in Matrigel under WNT-activating conditions, swiftly formed...
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