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Article

Assemblies of JAG1 and JAG2 determine tracheobronchial cell fate in mucosecretory lung disease

12 Jul 2022

Abstract excerpt

Mucosecretory lung disease compromises airway epithelial function and is characterized by goblet cell hyperplasia and ciliated cell hypoplasia. Goblet and ciliated cell types are derived from tracheobronchial stem/progenitor cells via a Notch-dependent mechanism. Although specific arrays of Notch receptors regulate cell fate determination, the function of the ligands Jagged1 (JAG1) and JAG2 is unclear. This study...

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PMID: 35819850
DOI: 10.1172/jci.insight.157380

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