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Article

In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.

Gastroenterology - 1 Jan 2015

Bartfeld Sina, Bayram Tülay, van de Wetering Marc, Huch Meritxell, Begthel Harry, Kujala Pekka, Vries Robert, Peters Peter J, Clevers Hans

Abstract excerpt

BACKGROUND & AIMS: We previously established long-term, 3-dimensional culture of organoids from mouse tissues (intestine, stomach, pancreas, and liver) and human intestine and pancreas. Here we describe conditions required for long-term 3-dimensional culture of human gastric stem cells. The technology can be applied to study the epithelial response to infection with Helicobacter pylori. METHODS: We generated...

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Identifiers

PMID: 25307862
DOI: 10.1053/j.gastro.2014.09.042
PMCID: PMC4274199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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