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The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires <i>Mist1</i>

12 Dec 2006

Abstract excerpt

Continuous regeneration of digestive enzyme (zymogen)-secreting chief cells is a normal aspect of stomach function that is disrupted in precancerous lesions (e.g. metaplasias, chronic atrophy). The cellular and genetic pathways that underlie zymogenic cell (ZC) differentiation are poorly understood. Here, we describe a gene expression analysis of laser capture microdissection purified gastric cell populations...

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PMID: 17164426
DOI: 10.1242/dev.02700

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