Article

<i>Myh10</i> deficiency leads to defective extracellular matrix remodeling and pulmonary disease

2018-09-11

Abstract excerpt

Impaired alveolar formation and maintenance are features of many pulmonary diseases that are associated with significant morbidity and mortality. In a forward genetic screen for modulators of mouse lung development, we identified the non-muscle myosin II heavy chain gene, Myh10 . Myh10 mutant pups exhibit cyanosis and respiratory distress, and die shortly after birth from differentiation defects in alveolar epit...

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Literature Corpus work: c2af3eb6-de20-5e9e-b3ce-14347ceec9ba
DOI: 10.1101/414268

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