Article

Loss of <i>Tbx4</i> Affects Postnatal Lung Development and Predisposes to Pulmonary Hypertension

2024-09-22

Abstract excerpt

Pulmonary arterial hypertension (PAH) is a progressive vascular disease characterized by remodeling of the precapillary pulmonary arteries. Genomic variation within the T-box 4 (TBX4) transcription factor is the second most common genetic cause of PAH, and can also cause severe lung developmental disorders with neonatal PH. Currently, the effect of TBX4 loss-of-function on later stages of lung development and pred...

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Literature Corpus work: 52b22ab6-3530-5759-a80d-459833887f56
DOI: 10.1101/2024.09.18.613783

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