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Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans

30 Apr 2002

Abstract excerpt

Pulmonary fibrosis is a progressive and largely untreatable group of disorders that affects up to 100,000 people on any given day in the United States. To elucidate the molecular mechanisms that lead to end-stage human pulmonary fibrosis we analyzed samples from patients with histologically proven pulmonary fibrosis (usual interstitial pneumonia) by using oligonucleotide microarrays. Gene expression patterns...

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PMID: 11983918
DOI: 10.1073/pnas.092134099

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