Article

Excessive Postnatal Smooth Muscle Differentiation in a Lung Specific Model of <i>TBX4</i> -related Pulmonary Hypertension

2025-03-29

Abstract excerpt

<h4>ABSTRACT</h4> Heterozygous TBX4 variants are the second most common genetic cause of pediatric pulmonary hypertension (PH), yet the mechanisms underlying the pathophysiology of TBX4-related lung disease remain poorly understood. We developed a lung mesenchyme-specific Tbx4 loss of function ( Tbx4cKO ) mouse model that bypasses embryonic lethality to investigate TBX4-related lung disease. Echocardiography o...

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Literature Corpus work: 48de3096-e3a3-5991-9802-d4350c0984a7
DOI: 10.1101/2025.03.26.645517

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