Article

Deregulation of multiple mechanisms shapes the onset of <i>LAMA2</i> -congenital muscular dystrophy

2024-01-24

Abstract excerpt

<h4>ABSTRACT</h4> LAMA2 -congenital muscular dystrophy (LAMA2-CMD) is the most common congenital muscular dystrophy. This often-lethal disease is triggered by mutations in LAMA2 , coding for laminin-α2 chain, a key extracellular matrix (ECM) component, prevalent in the skeletal muscle. Several phenotypes have been associated with LAMA2-CMD, however, it is not yet known what mechanisms are faulty, right at diseas...

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Literature Corpus work: 78cb4b17-8f03-5ab7-af84-b58458473899
DOI: 10.1101/2024.01.20.576409

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